These results may provide a better understanding of the relationships between vitamin D and these clinical parameters. Haplotype analysis confirmed the significance of the relationships between ApaI and FokI SNPs and parameters associated with inflammation and oxidative stress.Ĭonclusions: Genetic variations of VDR are associated with subtle changes in metabolic, inflammatory and oxidative stress markers. No significant associations were observed between the TaqI SNP and any of the parameters evaluated.
The minor allele A of ApaI was significantly associated with decreased serum tumor necrosis factor-α and 8-isoprostaglandin F2α in an additive mode (P=0.016 and P=0.020 respectively). Results: The homozygous major allele AA in the FokI SNP was associated with increased levels of high-density lipoprotein cholesterol in a recessive inheritance mode (P=0.025). Routine biochemistry, serum levels of interleukin-6, tumor necrosis factor-α, interferon-γ, 8-isoprostaglandin F2α and nitrates were determined. FokI, ApaI and TaqI SNPs of the VDR gene were genotyped. Methods: This is a cross-sectional study of a Caucasian Spanish population including 155 healthy children (87 males, 68 females) aged 10 to 14 years. The focus of this study was to explore associations between VDR single nucleotide polymorphisms (SNPs) and markers of inflammation and oxidative stress in vitamin D sufficient children. Furthermore, some mutations in the VDR can affect its functionality. Several studies have explored the effects of vitamin D deficiency in inflammatory disorders.
The interaction of the VDR with calcitriol modulates the expression of target genes involved in cell proliferation and cytokine production. The mechanism of action of the active form or calcitriol is mediated by the intracellular vitamin D receptor (VDR). Sara Ferrer-Suay 1, Eulalia Alonso-Iglesias 2, Miguel Tortajada-Girbés 1,3, Joaquín Carrasco-Luna 1,4, Pilar Codoñer-Franch 1,3^ġDepartment of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain 2Department of Biochemistry and Molecular Biology, University of Valencia, Valencia, Spain 3Service of Pediatrics, University Hospital Doctor Peset, Foundation for Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain 4Department of Experimental Sciences, Catholic University of Valencia, Valencia, SpainĬontributions: (I) Conception and design: P Codoñer-Franch (II) Administrative support: P Codoñer-Franch (III) Provision of study materials or patients: J Carrasco Luna, S Ferrer-Suay, M Tortajada-Girbés (IV) Collection and assembly of data: J Carrasco-Luna, S Ferrer-Suay, E Alonso-Iglesias (V) Data analysis and interpretation: All authors (VI) Manuscript writing: All authors (VII) Final approval of manuscript: All authors.īackground: Vitamin D has gone from being just one vitamin to being an important prohormone with multiple effects on different tissue types.
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